The concomitant usage of anticholinergic prescription drugs may possibly improve risk of urinary retention and/or significant constipation, which may result in paralytic ileus.
Study and observe these Guidance diligently. Go through it again every time you refill your prescription in the event that There exists new information and facts. Talk to your doctor When you've got any queries.
Keep at place temperature faraway from gentle and dampness. Usually do not retail store in the lavatory. Keep all medications far from small children and Animals. See also Warning part.
If concomitant use is critical, consider growing the OXYCONTIN dosage until finally secure drug consequences are attained.
This is especially important for elderly clients, who may be more delicate to the results of discomfort medicines. If a lot of of this medicine is taken for years, it might grow to be practice-forming (producing mental or Actual physical dependence).
Modify the dosage to acquire an suitable equilibrium concerning administration of suffering and opioid-associated adverse reactions.
As the use of OXYCONTIN exposes individuals and also other people towards the threats of opioid habit, abuse, and misuse, which can result in overdose and Demise, evaluate each affected person's danger prior to prescribing and reassess all sufferers consistently for the check here development of these behaviors and disorders [see Warnings and Safeguards (5.1)].
If the choice is designed to prescribe a benzodiazepine or other CNS depressant concomitantly by having an opioid analgesic, prescribe the bottom productive dosages and least durations of concomitant use. In patients now obtaining an opioid analgesic, prescribe a lower First dose on the benzodiazepine or other CNS depressant than indicated within the absence of the opioid, and titrate based on clinical reaction.
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Serotonin syndrome: Cases of serotonin syndrome, a perhaps daily life-threatening problem, are actually noted through concomitant usage of opioids with serotonergic medication.
Alert clients never to push or function harmful machinery Until They may be tolerant to the results of OXYCONTIN and know the way they can react into the medication.
Do not flush prescription drugs down the toilet or pour them right into a drain Except if instructed to take action. Effectively discard this item when it is actually expired or now not essential. For more particulars, examine the Medication Guide, or speak to your pharmacist or nearby squander disposal enterprise.
The concomitant utilization of OXYCONTIN with all cytochrome P450 3A4 inhibitors might result in an increase in oxycodone plasma concentrations, which could boost or lengthen adverse drug effects and will induce possibly fatal respiratory despair. Furthermore, discontinuation of a concomitantly utilised cytochrome P450 3A4 inducer may end in a rise in oxycodone plasma concentration.
• Just take OxyContin particularly as prescribed. Don't transform your dose unless your healthcare service provider tells you to.